Pathogen trafficking pathways and host phosphoinositide metabolism
نویسندگان
چکیده
منابع مشابه
Copper Transport and Trafficking at the Host–Bacterial Pathogen Interface
CONSPECTUS: The human innate immune system has evolved the means to reduce the bioavailability of first-row late d-block transition metal ions to invading microbial pathogens in a process termed "nutritional immunity". Transition metals from Mn(II) to Zn(II) function as metalloenzyme cofactors in all living cells, and the successful pathogen is capable of mounting an adaptive response to mitiga...
متن کاملThe Hijacking of Host Endocytic Trafficking by the Bacterial Pathogen
Two endo membrane systems; the secretory pathway and the Endocytic pathway both utilize vesicular trafficking to control movement in and out of the cell. In the secretory pathway, proteins synthesized in the Endoplasmic Reticulum (ER) are Trans located to the plasma membrane. In the Endocytic pathway, the endosomal and phagosomal trafficking to lysosome occurs via the early to late endosomal pa...
متن کاملTargeting pathogen metabolism without collateral damage to the host
The development of drugs that can inactivate disease-causing cells (e.g. cancer cells or parasites) without causing collateral damage to healthy or to host cells is complicated by the fact that many proteins are very similar between organisms. Nevertheless, due to subtle, quantitative differences between the biochemical reaction networks of target cell and host, a drug can limit the flux of the...
متن کاملSequestration of host metabolism by an intracellular pathogen.
For intracellular pathogens, residence in a vacuole provides a shelter against cytosolic host defense to the cost of limited access to nutrients. The human pathogen Chlamydia trachomatis grows in a glycogen-rich vacuole. How this large polymer accumulates there is unknown. We reveal that host glycogen stores shift to the vacuole through two pathways: bulk uptake from the cytoplasmic pool, and d...
متن کاملThe Arginine Decarboxylase Pathways of Host and Pathogen Interact to Impact Inflammatory Pathways in the Lung
The arginine decarboxylase pathway, which converts arginine to agmatine, is present in both humans and most bacterial pathogens. In humans agmatine is a neurotransmitter with affinities towards α2-adrenoreceptors, serotonin receptors, and may inhibit nitric oxide synthase. In bacteria agmatine serves as a precursor to polyamine synthesis and was recently shown to enhance biofilm development in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2009
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2009.06608.x